ISSN 1662-4009 (online)

ey0020.12-7 | Steroids | ESPEYB20

12.7. Preoperative circulating 11-oxygenated androgens are associated with metastasis-free survival in localized prostate cancer

C Dahmani , P Caron , D Simonyan , L Lacombe , A Aprikian , F Saad , M Carmel , S Chevalier , E Levesque , C Guillemette

Brief summary: In the prospective PROCURE study cohort (n=1783), 11-oxygenated androgens were studied in all men with newly diagnosed localized prostate cancer before undergoing radical prostatectomy. Data were related to clinical outcomes (e.g. metastatic disease). Levels of the adrenal androgen precursor 11b-OH-androstenedione were associated with progressive disease, while levels of the predominant bioactive 11-ketotestosterone and its metabolite 11-ketoandrosteron...