Abstract Search

In the past year, there were a large number of scientific publications on disorders of the thyroid gland or the hypothalamus-pituitary-thyroid (HPT) axis in children and adults. In this chapter, you will find a selection of the probably most impactful publications in this field published in the period June 2023 to July 2024, of importance to the discipline of pediatric endocrinology.To get you excited, here is a short overview: “Disruption of Notch ...

ey0016.11-14 | Treatment of Severe Obesity: Next Steps | ESPEYB16

11.14. Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review

L van Iersel , KE Brokke , RAH Adan , LCM Bulthuis , ELT van den Akker , HM van Santen

To read the full abstract: Endocr Rev. 2019;40(1):193–235This paper combines a comprehensive review of current knowledge on pathophysiologic mechanisms contributing to hypothalamic obesity in craniopharyngioma patients with a systematic literature review of intervention studies for weight management in this patient population. Findings of both reviews are merged into evidence-...

ey0018.9-8 | Genetic susceptibility to treatment-related gonadotoxicity | ESPEYB18

9.8. Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function

ALF van der Kooi , M van Dijk , L Broer , MH van den Berg , JSE Laven , FE van Leeuwen , CB Lambalk , A Overbeek , JJ Loonen , HJ van der Pal , WJ Tissing , B Versluys , D Bresters , CCM Beerendonk , CR Ronckers , M van der Heiden-van der Loo , GL Kaspers , ACH de Vries , LL Robison , MM Hudson , W Chemaitilly , J Byrne , C Berger , E Clemens , U Dirksen , J Falck Winther , SD Fossa , D Grabow , R Haupt , M Kaiser , T Kepak , J Kruseova , D Modan-Moses , SMF Pluijm , C Spix , O Zolk , P Kaatsch , JH Krijthe , LC Kremer , Y Yasui , RJ Brooke , AG Uitterlinden , M van den Heuvel-Eibrink , E Mvan Dulmen-den Broeder

Hum Reprod. 2021; 36: 1120–1133. https://pubmed.ncbi.nlm.nih.gov/33582778/This multi-centre retrospective cohort study identifies that common genetic variants in DNA repair genes modify the damage induced by alkylating agents on ovarian function, as assessed by low AMH levels.Alkylating agents are known to induce apoptosis of cancer cells by damaging DNA replicat...

ey0019.13-12 | Diabetes | ESPEYB19

13.12. Approach to diagnosing a pediatric patient with severe insulin resistance in low- or middle-income countries

AA van Heerwaarde , RCW Klomberg , CMA van Ravenswaaij-Arts , HK Ploos van Amstel , Toekoen A , F Jessurun , A Garg , DCM van der Kaay

d.vanderkaay@erasmusmc.nl or abhimanyu.garg@utsouthwestern.edu.J Clin Endocrinol Metab 2021, 106, 3621–3633. doi: 10.1210/clinem/dgab549Brief Summary: This expert perspective proposes that a thorough review of medical history and physical examination is generally sufficient to diagnose ...

ey0017.9-5 | Fertility-Related Issues | ESPEYB17

9.5. Leydig cell function in male survivors of childhood cancer: A report from the St Jude lifetime cohort study

W Chemaitilly , Q Liu , L van Iersel

To read the full abstract: J Clin Oncol. 2019;37(32):3018–3031. wassim.chemaitilly@stjude.orgThis retrospective study, with cross-sectional health outcomes analysis, evaluated Leydig cell function in 1516 childhood cancer survivors at a median duration of 22.0 years after cancer diagnosis. These patients are part of the St Jude Lifetime Cohort. An age- and sex-matched community control grou...

ey0018.9-6 | Surveillance strategies of endocrine complications | ESPEYB18

9.6. Female reproductive function after treatment of childhood acute lymphoblastic leukemia

R Roshandel , M van Dijk , A Overbeek , G Kaspers , C Lambalk , C Beerendonk , D Bresters , M van der Heiden-van der Loo , M van den Heuvel-Eibrink , L Kremer , J Loonen , H van der Pal , C Ronckers , W Tissing , B Versluys , F van Leeuwen , M van den Berg , E van Dulmen-den Broeder

Pediatr Blood Cancer. 2021; 68: e28894. https://pubmed.ncbi.nlm.nih.gov/33459500/This cross-sectional observational study examined reproductive function in a nationwide cohort of female childhood acute lymphoblastic leukemia (ALL) survivors.Self-reported reproductive characteristics (age at menarche, virginity status, desire for children, pregnancy rates, and adverse ...

ey0019.11-9 | New predictors of obesity development | ESPEYB19

11.9. Fat mass and fat-free mass track from infancy to childhood: New insights in body composition programming in early life

IA van Beijsterveldt , KS de Fluiter , LM Breij , M van der Steen , ACS Hokken-Koelega

joelh@broadinstitute.org Obesity (Silver Spring). 2021 Nov;29(11):1899–1906. doi: 10.1002/oby.23271. Epub 2021 Sep 21. https://pubmed.ncbi.nlm.nih.gov/34549538/Brief Summary: This longitudinal study assessed body composition in a cohort of children at ages 1, 3, and 6 months and 4 years (n...

ey0021.1-1 | New Mechanisms | ESPEYB21

1.1. SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability

Lettieri A. , Oleari R. , van den Munkhof M.H. , van Battum E.Y. , Verhagen M.G. , Tacconi C.

Brief Summary: This research identifies a role for SEMA6A in puberty onset by regulating median eminence vascular permeability.The authors elegantly use murine transgenics of Sema6a -/- combined with cell biology, biochemical assays and human genetics to identify a previously unknown role for Sema6a in regulating vascular permeability of endothelial cells within the median eminence (ME) to maintain neuroendocrine homeostasis. The role of SEMA6A ...

ey0021.2-6 | Systematic Reviews | ESPEYB21

2.6. Safety of Antenatal Predniso(lo)ne and Dexamethasone on Fetal, Neonatal and Childhood Outcomes: A Systematic Review

EMA Slob , JUM Termote , JW Nijkamp , der Kamp HJ van , den Akker ELT van

Brief Summary: This systematic review examined the impact of at least one trimester of pregnancy glucocorticoid treatment on pregnancy, neonatal and child outcomes. It included human studies published after 2000 (to 2022) to avoid earlier work where maternal and newborn care may have been outdated. It identified 23 eligible papers, most described cohort studies (not all had control groups), 3 case reports or series and one meta-analysis of dexamethasone (DEX) to prevent virili...

ey0021.4-5 | Important for Clinical Practice | ESPEYB21

4.5. Cerebrovascular abnormalities in adults born SGA at 12 years after growth hormone cessation compared to controls

DJ Dorrepaal , WJ Goedegebuure , L Smagge , M van der Steen , A van der Lugt , ACS Hokken-Koelega

Brief Summary: This single-center, prospective study used brain MRI to assess the prevalence of cerebrovascular abnormalities in a large cohort of adult patients born SGA and treated with GH during childhood, 12 years after rhGH treatment cessation. GH treatment was not associated with a higher incidence of aneurysms, intracerebral hemorrhages, microbleeds or other vascular abnormalities.The French population-based cohort of the Safety and Appropriatenes...

ESPE Yearbook of Paediatric Endocrinology

3. Thyroid