ESPE Yearbook of Paediatric Endocrinology

Brief summary: This study examined glycemic control following treatment with once-weekly exenatide 2 mg (Bydureon, AstraZeneca) in youth with T2D which was not optimally controlled. At 24 weeks, exenatide was superior to placebo in lowering HbA1c (least squares mean change, −0.36% with exenatide vs. +0.49% with placebo), with a between-group difference of −0.85%.Comment: The story of the development of exenatide is fascinating. It starts with...

Endocr J. 2021 Apr 3. doi: 10.1507/endocrj.EJ21-0050. PMID: 33814485.Mizue Fujii and colleagues retrospectively evaluated the pituitary function in 67 and 111 adult patients with Rathke’s cleft cyst (RCC) and non-functioning pituitary adenoma (NFA), respectively. The study population represented consecutive patients encountered in their institute. They found that RCCs were smaller t...

J Adolesc Health. 2020 Jun;66(6):658–665. doi: 10.1016/j.jadohealth.2020.01.007.https://www.ncbi.nlm.nih.gov/pubmed/32115323This systematic review is inspired by the large discordance between the high number of transgender individuals who express a desire for genetic parenthood compared to the very low number who ult...

Cochrane Database Syst Rev. 2021 Dec 21;12(12):CD013309. doi: 10.1002/14651858.CD013309.pub3. PMID: 34931697.Brief Summary: This systematic review assessed the evidence for continuous glucose monitoring (CGM) to prevent morbidity and mortality in preterm infants. There was uncertainty about the safety of CGM and the available management algorithms, and many morbidities remain unreporte...

Diabetes Care. 2021 Nov;44(11):2536-2541. doi: 10.2337/dc21-0327. PMID: 34475030.Brief Summary: This retrospective case control study investigated changes in the metabolic profile in newborn screening of infants born to mothers who had been treated with metformin. Treatment with metformin during pregnancy was associated with subtle changes in metabolites in the newborn screening.<p class="abste...

Horm Res Paediatr. 2021;94(11-12):456-466. PMID: 35086092Brief Summary: This study reports 2 girls with a complex phenotype associated with severe short stature and IUGR who were diagnosed with a de novo 17p13. 3 deletion by array-CGH. The deletion involved the CRK gene that transcribes for Crk protein, a component of GH and IGF-I receptor signaling pathways. In vitro assay confirmed defective CRK expression and GH/IGF1 signali...

To read the full abstract: Diabetes Care. 2020 Apr;43(4):906–908. doi: 10.2337/dc19-2126. Epub 2020 Jan 23. PMID: 31974101Antenatal corticosteroid administration prior to planned cesarean section in early labour reduces by >50% the risk of admission to the neonatal intensive care unit for respiratory distress syndrome and transient tachypnea of the newborn. However, among pregnant women wit...

To read the full abstract: Diabetes Care. 2020. doi: 10.2337/dc20-0723Short summary: In this observational cohort of hospitalised COVID-19 patients in Italy, patients who had hyperglycaemia, with or without diabetes, were at higher risk for severe COVID disease than normoglycaemic patients. Insulin infusion was effective for achieving glycaemic targets and reducing mortality in patients...

To read the full abstract: N Engl J Med. 2020;382(16):1520–30. doi: 10.1056/NEJMoa1913805Short summary: Inclisiran (a small interfering double-stranded RNA against PCSK9) is superior to placebo in reducing LDL-C among individuals with heterozygous Familial Hypercholesterolemia who are already on statins and ezetimibe.Comment: Proprotein convertas...

To read the full abstract: Curr Biol 2019;29:813–822 e4.In vertebrates, puberty is the critical transitional step which leads to major somatic changes and the acquisition of the reproduction function. At the molecular level, puberty equates to the reactivation of the gonadotropic axis after a period of childhood quiescence, and hence increases sex steroid production. This reactivati...