ISSN 1662-4009 (online)

ey0019.3-15 | Paediatric thyroid cancer | ESPEYB19

3.15. Association between radioactive iodine treatment for pediatric and young adulthood differentiated thyroid cancer and risk of second primary malignancies

E Pasqual , S Schonfeld , LM Morton , D Villoing , C Lee , de Gonzalez A Berrington , CM Kitahara

J Clin Oncol. 2022 May 1;40(13):1439-1449. doi: 10.1200/JCO.21.01841. Epub 2022 Jan 19. PMID: 35044839Brief Summary: This retrospective study showed that children and young adults (< 45 years) treated with radioactive iodine (RAI) for primary Differentiated Thyroid Cancer (DTC) have increased risks for leukemia and solid cancers, particularly beyond 20 years after treatment.<p class="abs...

ey0019.5-9 | Translational highlights | ESPEYB19

5.9. PTH and FGF23 exert interdependent effects on renal phosphate handling: evidence from patients with hypoparathyroidism and hyperphosphatemic familial tumoral calcinosis treated with synthetic human PTH 1-34

D Ovejero , IR Hartley , LF de Castro Diaz , E Theng , X Li , RI Gafni , MT Collins

J Bone Miner Res. 2022 Feb;37(2):179-184.Abstract: https://pubmed-ncbi-nlm-nih-gov/34464000/In Brief: Fibroblast growth factor 23 (FGF23) and parathyroid hormone (PTH) both negatively regulate serum phosphate by increasing renal phosphate excretion. The clinical observation that both PTH and FGF23 are needed for adequate renal phosphate handling is confirmed in this experimental patient stu...

ey0019.5-12 | Translational highlights | ESPEYB19

5.12. Premature growth plate closure caused by a hedgehog cancer drug is preventable by co-administration of a retinoid antagonist in mice

E Koyama , C Mundy , C Saunders , J Chung , SE Catheline , D Rux , M Iwamoto , M Pacifici

J Bone Miner Res 36, 1387–1402. (2021)Abstract: https://pubmed-ncbi-nlm-nih-gov/33724538/In brief: Premature growth plate closure under anti-hedgehog treatment is caused by impaired retinoic acid metabolism in growth plate progenitor cells. In this mouse model, administration of retinoic acid receptor blockers rescued the phenotype and normalized growth plate maturation.<p class="a...

ey0019.7-3 | Clinical Guidance | ESPEYB19

7.3. FSH-stimulated inhibin b (FSH-iB): a novel marker for the accurate prediction of pubertal outcome in delayed puberty

S Chaudhary , R Walia , A Bhansali , D Dayal , N Sachdeva , T Singh , SK Bhadada

J Clin Endocrinol Metab. 2021 Aug 18;106(9):e3495-e3505. doi: 10.1210/clinem/dgab357. PMID: 34010394https://academic.oup.com/jcem/article-abstract/106/9/e3495/6278376Brief Summary: This prospective interventional study evaluates the stimulation of inhibin B by exogenous FSH as a promising predictor of spontaneous ...

ey0019.8-6 | Important for Clinical Practice | ESPEYB19

8.6. Characteristics of growth in children with classic Congenital Adrenal Hyperplasia due to 21-hydroxylase deficiency during adrenarche and beyond

T Troger , G Sommer , M Lang-Muritano , D Konrad , B Kuhlmann , U Zumsteg , CE Fluck

J Clin Endocrinol Metab. 2022; 107(2): e487-e499. PMID: 34599587https://pubmed.ncbi.nlm.nih.gov/34599587/Brief Summary: This study describes the growth of adequately treated children with classical Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency during adrenarche and beyond. Patients with and without significant bone age advancement, and thus differing height prediction...

ey0019.9-9 | Fertility issues and reproductive outcomes in childhood cancer survivors | ESPEYB19

9.9. Parenthood among men diagnosed with cancer in childhood and early adulthood: trends over time in a Danish national cohort

Sylvest R. , Vassard D. , Schmidt L. , Schmiegelow K. , Macklon K.T. , Forman J.L. , Pinborg A.

randi.lykke-sylvest@regionh.dk Human Reproduction, Vol.36, No.9, pp. 2576–2586, 2021. PMID: 34166497.Brief Summary: This Danish register-based cohort study investigated the rate of fatherhood among 9,353 men diagnosed with cancer during childhood or early adulthood (CSs), compared with 1,386,493 age-matched males without cancer. CSs became fathers slightly less frequently than controls (36...

ey0019.11-13 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.13. Weight gain and obesity rates in transgender and gender-diverse adults before and during hormone therapy

M Kyinn , K Banks , SY Leemaqz , E Sarkodie , D Goldstein , MS Irwig

mirwig@bidmc.harvard.edu Int J Obes (Lond). 2021 Dec;45(12):2562–2569. doi: 10.1038/s41366-021-00935-x. Epub 2021 Aug 16. PMID: 34400797. https://pubmed.ncbi.nlm.nih.gov/34400797/Brief Summary: This retrospective chart review of 470 ethnically diverse transgender and gender diverse in...

ey0019.13-3 | Improving access to healthcare in pediatric endocrinology and diabetes | ESPEYB19

13.3. The role of non-governmental organizations in strengthening healthcare systems in low- and middle-income countries: lessons from Sante Diabete in Mali

B Besancon , A Sidibe , DS Sow , O Sy , J Ambard , JS Yudkin , D Beran

David.Beran@unige.ch Glob. Health Action 2022, VOL. 15, 2061239; doi: 10.1080/16549716.2022.2061239Brief Summary: In this perspective, the authors argue that non-governmental organisations (NGO), such as Santé Diabète, can play a role in the strengthening of health systems and can improve leadership and governance, service delivery and...

ey0019.13-9 | Diabetes | ESPEYB19

13.9. Global estimates of incidence of type 1 diabetes in children and adolescents: results from the International Diabetes Federation atlas, 10th edition

GD Ogle , S James , D Dabelea , C Pihoker , J Svennson , J Maniam , EL Klatman , CC Patterson

grahamo@diabetesnsw.com.au Diabetes Res Clin Pract 2022, 183:109083. doi: 10.1016/j.diabres.2021.109083Brief Summary: The incidence of Type 1 diabetes (T1D) in children and adolescents is increasing in many nations. The 10th edition of the International Diabetes Federation Atlas reports that an estimated 108,300 youth aged < 15 years a...

ey0019.13-17 | Endocrinology | ESPEYB19

13.17. Health-related quality of life and fatigue perception in children with congenital adrenal hyperplasia: a developing nation perspective

R Daniel , J Yadav , R Kumar , P Malhi , A Sharma , D Dayal

jai1984yadav@gmail.com Pediatr Endocrinol Diabetes Metab 2021; 27: 266–271. doi: 10.5114/pedm.2021.109269Brief Summary: The questionnaire-based case control study found that children with classical congenital adrenal hyperplasia (CAH) in northern India reported lower quality of life (QOL), poorer sleep and increased fatigue compared to healthy...