ESPEYB15 11 Obesity and Weight Regulation BAT: The story goes on (3 abstracts)
11.17 Cold-induced brown adipose tissue activity alters plasma fatty acids and improves glucose metabolism in men
Iwen KA , Backhaus J , Cassens M , Waltl , M , Hedesan OC , Merkel M , Heeren J , Sina C , Rademacher L , Windjäger A , Haug AR , Kiefer FW , Lehnert H & Schmid SM
University Hospital Schleswig-Holstein, Lübeck, Germany
To read the full abstract: JCEM 2017,102(11):4226-4234
It has been recently demonstrated that activation of brown adipose tissue (BAT) in humans improves glucose homeostasis and insulin sensitivity and is associated with accelerated lipid metabolism (3, 4), suggesting BAT activation as an option not only for obesity prevention, but also in diabetes management. There is recent evidence that cold exposure regulates insulin secretion in rats (5), but this has not been investigated in humans so far. The present study indicates that insulin secretion is unaffected by cold exposure in humans, at least in the short term. However, mouse studies usually use longer periods of cooling, which is infeasible in humans. Thus, it could be that long-term cold adaptions would have an influence on insulin secretion in humans as well. It is not clear whether insulin secretion is altered by sympathetic activation alone or whether BAT is involved in this process. It would be interesting to see whether BAT activation would have similar or different outcome in diabetic, insulin-resistant patients.
1. Chondronikola, M. et al. Brown Adipose Tissue Improves Whole Body Glucose Homeostasis and Insulin Sensitivity in Humans. Diabetes 2014. doi:10.2337/db14-0746
2. Chondronikola, M. et al. Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metab. 2016. doi:10.1016/j.cmet.2016.04.029
3. Morton, G. J. et al. Evidence that the sympathetic nervous system elicits rapid, coordinated, and reciprocal adjustments of insulin secretion and insulin sensitivity during cold exposure. Diabetes 2017; 66, 823–834.
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ESPE Yearbook of Paediatric Endocrinology
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