ISSN 1662-4009 (online)

Volume 15 | ESPEYB15 | Next issue

Yearbook of Paediatric Endocrinology 2018

ey0015.4-13 | New paradigms | ESPEYB15

4.13 An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth

T Uchimura , JM Hollander , DS Nakamura , Z Liu , CJ Rosen , I Georgakoudi , L Zeng

To read the full abstract: Development 2017; 144:3533-3546Endochondral ossification is the process by which the embryonic cartilaginous scaffold of most bones is gradually replaced by bone. During this process chondrocytes proliferate, undergo hypertrophy and maturation and form the growth plate, essential for bone growth. Postnatal bone growth is tightly regulated by both systemic and lo...