ISSN 1662-4009 (online)

Volume 15 | ESPEYB15 | Next issue

Yearbook of Paediatric Endocrinology 2018

5 Bone, Growth Plate and Mineral Metabolism

Klotho in the control of osteocyte activity

ey0015.5-12 | Klotho in the control of osteocyte activity | ESPEYB15

5.12 Klotho expression in osteocytes regulates bone metabolism and controls bone formation

H Komaba , J Kaludjerovic , DZ Hu , K Nagano , K Amano , N Ide , T Sato , MJ Densmore , JI Hanai , H Olauson , T Bellido , TE Larsson , R Baron , B Lanske

To read the full abstract: Kidney Int 2017;92:599-611Klotho was originally identified as a senescence-related protein because mice carrying hypomorphic Klotho alleles (kl/kl) develop premature aging with low bone turnover and osteoporosis. Primary function of Klotho is to form a specific receptor complex with fibroblast growth factor (FGF) receptor 1 (FGFR1) through which it mediates the bio...