ISSN 1662-4009 (online)

Volume 15 | ESPEYB15 | Next issue

Yearbook of Paediatric Endocrinology 2018

8 Adrenals

New Concerns

ey0015.8-15 | New Concerns | ESPEYB15

8.15 Cognitive impairment in adolescents and adults with congenital adrenal hyperplasia

L Karlsson , A Gezelius , A Nordenström , T Hirvikoski , S Lajic

To read the full abstract: Clin Endocrinol (Oxf). 2017; 87(6): 651-659Patients with CAH are treated with lifelong glucocorticoid (GC) replacement therapy and, for the classic form of the disease, treatment with fludrocortisone is also necessary. During different periods throughout life, it may be difficult to achieve optimal dosing of GC replacement therapy, leading to over- or under-treatment and, t...

ey0015.8-16 | New Concerns | ESPEYB15

8.16 Quantitative brain MRI in congenital adrenal hyperplasia: in vivo assessment of the cognitive and structural impact of steroid hormones

EA Webb , L Elliott , D Carlin , M Wilson , K Hall , J Netherton , J Reed , TG Barrett , V Salwani , JD Clayden , W Arlt , N Krone , AC Peet , AG Wood

To read the full abstract: J Clin Endocrinol Metab. 2018;103(4):1330-1341Glucocorticoids exert an inverted U-shaped influence on human cognition, particularly on acquiring and consolidating memory (25), whereas androgens have an overall beneficial effect on cognitive control, verbal memory, and spatial cognition in humans (26). Although previous studies in patients with CAH have con...