ISSN 1662-4009 (online)

Volume 15 | ESPEYB15 | Next issue

Yearbook of Paediatric Endocrinology 2018

9 Oncology and chronic disease

Late effects of tumour therapy: molecular evidences of premature cellular aging

ey0015.9-4 | Late effects of tumour therapy: molecular evidences of premature cellular aging | ESPEYB15

9.4 Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging

H Ariffin , MS Azanan , SS Abd Ghafar , L Oh , KH Lau , T Thirunavakarasu , A Sedan , K Ibrahim , A Chan , TF Chin , FF Liew , S Jeyamogan , ES Rosli , R Baharudin , TY Yap , R Skinner , SH Lum , P Hainaut

To read the full abstract: Cancer. 2017;123:4207-4214Metabolic syndrome and early cardiovascular disease are well-known long-term complications of cancer treatment during childhood, but the underlying causes are still unclear. It had been already demonstrated that the abnormalities of the immune system, that are characteristic of the elderly population, may become evident earlier in childhood cancer...