ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

ey0016.12-11 | Lipid Metabolism | ESPEYB16

12.11. Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells

J Sandhu , S Li , L Fairall , SG Pfisterer , JE Gurnett , X et al. Xiao

Cell. 2018; 175(2): 514–29 e20.URL: The enigma of how cholesterol is transported within cells has been solved in these experimental mouse models and structural imaging studies by the discovery of the proteins Aster A, B and C, which serve as a molecular bridge for the transfer of cholesterol from the pl...

ey0016.12-12 | Lipid Metabolism | ESPEYB16

12.12. Orlistat therapy for children with type 1 hyperlipoproteinemia: a randomized clinical trial

N Patni , C Quittner , A Garg

Journal of Clinical Endocrinology and Metabolism. 2018; 103(6): 2403–7.URL: Orlistat therapy reduced serum triglycerides by 50–60% in two children with Type 1 hyperlipoproteinemia (T1HLP) in a randomized, open-label, crossover trial with four periods and two sequences. The treatment was safe and is suggested as fir...

ey0016.12-13 | Lipid Metabolism | ESPEYB16

12.13. Marine n-3 fatty acids and prevention of cardiovascular disease and cancer

JE Manson , NR Cook , IM Lee , W Christen , SS Bassuk , S Mora , H Gibson , CM Albert , D Gordon , T Copeland , D D'Agostino , G Friedenberg , C Ridge , V Bubes , EL Giovannucci , WC Willett , JE Buring , VITAL Research Group Buring

To read the full abstract: N Engl J Med 2019;380:23-32.Summary: In this randomized primary prevention placebo-controlled trial of 25,871 US adults, with a two-by-two factorial design, supplements with omega-3 did not lower the overall incidence of adverse cardiovascular events or cancer compared to a placebo.Comment: Omega-3 fatty acids are polyun...

ey0016.12-14 | Lipid Metabolism | ESPEYB16

12.14. An integrative systems genetic analysis of mammalian lipid metabolism

BL Parker , AC Calkin , MM Seldin , MF Keating , EJ Tarling , P Yang , SC Moody , Y Liu , EJ Zerenturk , EJ Needham , ML Miller , BL Clifford , P Morand , MJ Watt , RCR Meex , KY Peng , R Lee , K Jayawardana , C Pan , NA Mellett , JM Weir , R Lazarus , AJ Lusis , PJ Meikle , DE James , TQ de Aguiar Vallim , BG Drew

Nature 2019;567:187–193.URL Novel diagnostic and prognostic biomarkers in the blood that can predict early fatty liver disease were identified, using a proteomic and lipidomic-wide systems genetic approach in 107 genetically distinct mouse strains. In addition, the novel lipid-regulatory protein, PSMD9, was identified as...