ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

3. Thyroid

Congenital Hypothyroidism

ey0016.3-7 | Congenital Hypothyroidism | ESPEYB16

3.7. Incidence of congenital hypothyroidism over 37 Years in Ireland

N McGrath , CP Hawkes , CM McDonnell , D Cody , SM O'Connell , PD Mayne , NP Murphy

To read the full abstract: Pediatrics. 2018;142(4). pii: e20181199.This unique study investigated the incidence of congenital hypothyroidism from the start of the newborn screening in 1979 to 2016. The authors report a marked increase in incidence from 0.27 cases per 1000 live births in 1979–1991 to 0.41 in 1992–2004 and 0.65 in 2005–2016.A major str...

ey0016.3-8 | Congenital Hypothyroidism | ESPEYB16

3.8. Newborn screening for primary congenital hypothyroidism: estimating test performance at different TSH thresholds

RL Knowles , J Oerton , T Cheetham , G Butler , C Cavanagh , L Tetlow , C Dezateux

To read the full abstract: J Clin Endocrinol Metab. 2018;103:3720–28.This nationwide prospective surveillance study aimed to estimate the performance of the current UK recommended TSH threshold (10 mU/L on day 5 after birth) for newborn blood spot screening compared to lower thresholds: 8 mU/L and 6 mU/L. Over a 12-month period, the authors included all patients with positive TSH ba...

ey0016.3-9 | Congenital Hypothyroidism | ESPEYB16

3.9. Early determinants of thyroid function outcomes in children with congenital hypothyroidism and a normally located thyroid gland: a regional Cohort Study

C Saba , S Guilmin-Crepon , D Zenaty , L Martinerie , A Paulsen , D Simon , C Storey , S Dos Santos , J Haignere , D Mohamed , JC Carel , J Leger

To read the full abstract: Thyroid. 2018;28:959–67.This observational single center study aimed to identify predictors of transient versus permanent congenital hypothyroidism in patients with thyroid gland in situ diagnosed at birth. Strengths of the study are the prospectively documented clinical, biochemical and radiological parameters, the high inclusion rate, a...