ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

8. Adrenals

New Mechanisms

ey0016.8-2 | New Mechanisms | ESPEYB16

8.2. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress

C Steenblock , MF Rubin de Celis , LF Delgadillo Silva , V Pawolski , A Brennand , M Werdermann , I Berger , A Santambrogio , M Peitzsch , CL Andoniadou , AV Schally , SR Bornstein

To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(51): 12997–13002.Humans are constantly challenged by multiple stressors, to which the body’s response and adaptation are essential. The adrenal gland plays a major role in the response to both physiological challenges and stress. Maintenance of the adrenal is partly accomplished by proliferation and differentiat...

ey0016.8-3 | New Mechanisms | ESPEYB16

8.3. Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

M Mathieu , C Drelon , S Rodriguez , H Tabbal , A Septier , C Damon-Soubeyrand , T Dumontet , A Berthon , I Sahut-Barnola , C Djari , M Batisse-Lignier , JC Pointud , D Richard , G Kerdivel , MA Calmejane , V Boeva , I Tauveron , AM Lefrancois-Martinez , A Martinez , P Val

To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(52): E12265–E12274.The adrenal cortex plays a central role in regulating body homeostasis through the production of glucocorticoids and mineralocorticoids that control many important physiologic functions, such as metabolism, inflammation and arterial blood pressure. The production of these hormones, known as steroid...

ey0016.8-4 | New Mechanisms | ESPEYB16

8.4. Associations between adrenarcheal hormones, amygdala functional connectivity and anxiety symptoms in children

MEA Barendse , JG Simmons , ML Byrne , G Patton , L Mundy , CA Olsson , ML Seal , NB Allen , S Whittle

To read the full abstract: Psychoneuroendocrinology. 2018; 97: 156–163.Anxiety disorders are common in childhood and adolescence and the transition from childhood to adolescence seems to be a vulnerable period for the development of anxiety symptoms. This article elucidates the impact of androgens (DHEA, DHEAS and testosterone) on functional connectivity of the amygdala while ...