ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

9. Oncology and Chronic Disease

Metabolic and Cardiovascular Risk in Cancer Survivors

ey0016.9-2 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.2. The late effects of radiation therapy on skeletal muscle morphology and progenitor cell content are influenced by diet-induced obesity and exercise training in male mice

D D'Souza , S Roubos , J Larkin , J Lloyd , R Emmons , H Chen , M De Lisio

To read the full abstract: Sci Rep. 2019 Apr 30; 9(1): 6691.In recent years, improved knowledge of the metabolic risks in childhood cancer survivors (CCS) has increasingly focused research on modifiable factors and preventive strategies (1–2). It is well known that therapeutic irradiation can cause detrimental changes in body composition, but it is still unknown whether the specific...

ey0016.9-3 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.3. Insulin and glucose homeostasis in childhood cancer survivors treated with abdominal radiation: A pilot study

DN Friedman , P Hilden , CS Moskowitz , SL Wolden , ES Tonorezos , Z Antal , D Carlow , S Modak , NK Cheung , KC Oeffinger , CA Sklar

To read the full abstract: Pediatr Blood Cancer. 2018; 65(11): e27304.Observational studies in large cohorts of cancer survivors have reported that cancer survivors exposed to abdominal radiation have an increased risk of both insulin-dependent and non-insulin-dependent diabetes mellitus, with a prolonged latency between radiation exposure and diabetes onset. The irradiation of the pancr...

ey0016.9-4 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.4. Diabetes risk in childhood cancer survivors: A population-based study

IC Lega , JD Pole , PC Austin , C Lau , PC Nathan , NN Baxter

To read the full abstract: Can J Diabetes. 2018 Oct; 42(5): 533.This retrospective population-based study focused on diabetes prevalence in childhood cancer survivors (CCSs) using administrative health care databases of the Canadian National Health System. The authors compared 10,438 CCSs (mean age 10.7±6.8 years; mean follow-up time 11.2±6.9 years) with 52,190 age- and sex-mat...

ey0016.9-5 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.5. Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus

R Nakagawa , A Hosokawa-Tsuji , Y Aoki , K Takasawa , M Maru , K Nakajima , A Sutani , Y Miyakawa , D Tomizawa , K Kashimada , T Morio

To read the full abstract: Endocrine. 2018 Jul; 61(1):76Hematopoietic stem cell transplantation (HSCT) is a curative treatment for life-threatening malignancies. However, late HSCT adverse effects cause substantial morbidity among long-term survivors. Metabolic complications, such as diabetes mellitus and hyperlipidemia, are the major late effects of pediatric HSCT, but the pathogenesis ...

ey0016.9-6 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.6. Late cardiovascular morbidity and mortality following pediatric allogeneic hematopoietic cell transplantation

CN Duncan , R Brazauskas , J Huang , BE Shaw , NS Majhail , BN Savani , MED Flowers , M Battiwalla , K Beebe , AC Dietz , CC Dvorak , R Giller , DA Jacobsohn , M Kletzel , PL Martin , ER Nemecek , B Nuechterlein , JA Talano , MA Pulsipher , KS Baker

To read the full abstract: Bone Marrow Transplant. 2018 Oct; 53 (10):1278Early cardiovascular disease is relatively common among childhood cancer survivors (CCS). A high risk of accelerated atherosclerosis and a 8.2-fold higher cardiac mortality rate have been reported (1). Arterial stiffness, an independent risk factor for cardiovascular morbidity and mortality in adults, seems to incre...

ey0016.9-7 | Metabolic and Cardiovascular Risk in Cancer Survivors | ESPEYB16

9.7. No evidence of overweight in long-term survivors of childhood cancer after glucocorticoid treatment

FN Belle , R Kasteler , C Schindera , M Bochud , RA Ammann , NX von der Weid , CE Kuehni , Swiss Pediatric Oncology Group (SPOG)

To read the full abstract: Cancer. 2018 Sep 1; 124 (17): 3576.Glucocorticoids still represent one of the pillars in the treatment of paediatric hematologic malignancies, but they cause excessive weight gain through several mechanisms. However, it is unclear whether these glucocorticoids have a long-lasting effect on body weight, because studies have focused mainly on the acute effects du...