ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

ey0018.12-8 | Metabolic Syndrome | ESPEYB18

12.8. COVID-19 and metabolic diseases: a heightened awareness of health inequities and a renewed focus for research priorities

WT Cefalu , GP Rodgers

Cell Metab. 2021 Mar 2;33(3):473–478. doi: 10.1016/j.cmet.2021.02.006. PMID: 33581046.In brief: This perspective paper discusses the observed disparities for metabolic diseases in regard to COVID-19. Disparities stem from systemic differences in access to care, environmental exposures and other sociodemographic factors.Comment: Hopefully, by...

ey0018.12-9 | Metabolic Syndrome | ESPEYB18

12.9. Sugar-Induced obesity and insulin resistance are uncoupled from shortened survival in drosophila

E Van Dam , LAG van Leeuwen , E Dos Santos , J James , L Best , C Lennicke , AJ Vincent , G Marinos , A Foley , M Buricova , JB Mokochinski , HB Kramer , W Lieb , M Laudes , A Franke , C Kaleta , HM Cocheme

Cell Metab. 2020; 31(4):710–725.e7. doi: 10.1016/j.cmet.2020.02.016. PMID: 32197072.In brief: High-sugar diets cause thirst, obesity and metabolic dysregulation, leading to insulin resistance, the MetS, T2DM and shortened lifespan. This study shows that high sugar diets induce dehydration in adult Drosophila. Water supplementation fully rescued the shortened lifespan, but ...

ey0018.12-10 | Metabolic Syndrome | ESPEYB18

12.10. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

LO Huang , A Rauch , E Mazzaferro , M Preuss , S Carobbio , CS Bayrak , N Chami , Z Wang , UM Schick , N Yang , Y Itan , A Vidal-Puig , M den Hoed , S Mandrup , TO Kilpelainen , RJF Loos

Nat Metab. 2021 Feb;3(2):228–243. doi: 10.1038/s42255-021-00346-2. PMID: 33619380.In brief: In this genome-wide association study, the authors were able to disentangle the mechanism that uncouples adiposity from its known cardiometabolic complications. They identified 62 genomic loci, at which the same allele is associated with both higher adiposity and lower cardiometabol...

ey0018.12-11 | Metabolic Syndrome | ESPEYB18

12.11. The effect of green Mediterranean diet on cardiometabolic risk; a randomised controlled trial

G Tsaban , A Yaskolka Meir , E Rinott , H Zelicha , A Kaplan , A Shalev , A Katz , A Rudich , A Tirosh , I Shelef , I Youngster , S Lebovitz , N Israeli , M Shabat , D Brikner , E Pupkin , M Stumvoll , J Thiery , U Ceglarek , JT Heiker , A Korner , K Landgraf , M von Bergen , M Bluher , MJ Stampfer , I Shai

Heart. 2020 Nov 23:heartjnl-2020-317802. doi: 10.1136/heartjnl-2020-317802. PMID: 33234670.In brief: This parallel-arm trial randomly assigned 294 adults with abdominal obesity/dyslipidemia to 1 of 3 dietary guidelines: healthy diet; Mediterranean diet; or ‘green Mediterranean’ diet. All groups received physical activity guidelines. Weight loss was higher in the two...

ey0018.12-12 | Metabolic Syndrome | ESPEYB18

12.12. Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity - a preview randomized clinical trial

E Dorenbos , M Drummen , T Adam , J Rijks , B Winkens , JA Martinez , S Navas-Carretero , G Stratton , N Swindell , P Stouthart , K Mackintosh , M Mcnarry , A Tremblay , M Fogelholm , A Raben , M Westerterp-Plantenga , A Vreugdenhil

Pediatr Obes. 2021 Jan;16(1):e12702. doi: 10.1111/ijpo.12702. PMID: 32681547.In brief: This randomized parallel trial, conducted in the Netherlands, the United Kingdom and Spain, assessed the impact of a high protein/low glycaemic diet vs. medium protein/medium glycaemic diet in reducing insulin resistance in 126 adolescents with overweight/obesity (mean age 13.6±2.2 years). At 2 ...