ESPE Yearbook of Paediatric Endocrinology

Pediatrics. 2020 Sep;146(3):e20200265. doi: 10.1542/peds.2020-0265. PMID: 32778539.In brief: This cross-sectional analysis of a nationally representative US sample showed that 25.5% of US children and adolescents (10.6 million in 2016) are eligible for screening for diabetes according to American Diabetes Association (ADA) criteria. The eligibility criteria showed l...

PLoS One. 2020 Jun 26;15(6):e0234970. doi: 10.1371/journal.pone.0234970.In brief: Metabolite signatures were compared between children with normal weight, obesity, and both obesity and T2DM, by measuring 273 analytes in fasting plasma and a 24-hour urine sample. Twenty-two urine metabolites were uniquely associated with T2DM. Adolescents with T2DM have altered purine nucleoti...

Diabetes Care. 2020 Oct;43(10):2544–2552. doi: 10.2337/dc19-2164. PMID: 32778556.In brief: This cross-sectional study compared bone mineral density (BMD), lean body mass and abdominal visceral fat between 180 individuals with T2DM, 226 with obesity, and 238 with normal weight, aged 10–23 years. The findings suggest that T2DM in youth may have a detrimental effect on bone accru...

Can J Diabetes. 2021 Jan 22:S1499–2671(21)00018-6. doi: 10.1016/j.jcjd.2021.01.011. PMID: 33722492.In brief: The presence of depressive symptoms was assessed in 197 adolescents and young adults (ages 12 to 24 years) with T2DM. 19% reported elevated depressive symptoms and 19% admitted thoughts of self-harm. Older age, shorter diabetes duration, higher HbA1c level, being no...

Diabetes Care. 2021 Apr 26:dc202308. doi: 10.2337/dc20-2308. PMID: 33905344.In brief: The multicenter SEARCH for Diabetes in Youth Study assessed cognitive function in adolescents and young adults with type 1 diabetes mellitus (T1DM) (n=1095) or T2DM (n=285). Mean age was 21.6±5.1 years and mean diabetes duration 11.0±3.4 years. Having T2DM was associated wit...

Cardiovasc Diabetol. 2020 Oct 6;19(1):168. 10.1186/s12933-020-01143-z. PMID: 33023586.In brief: The impact of immigration on the risk of early-onset T2DM (before age 40 years) was assessed in a nationwide cohort. Data on 93 806 native Israelis and 27 684 Israelis of Ethiopian origin, assessed at a mean age 17.5 years, were linked to the Israeli National Diabetes Registry. After adjustment fo...

BMJ. 2020 Dec 10;371:m4337. doi: 10.1136/bmj.m4337.In brief: Owners of dogs which have with diabetes are more likely to develop T2DM themselves than owners of dogs without diabetes. The underlying mechanisms might include shared diabetogenic health behaviours and environmental exposures. No shared risk of diabetes was found between cat owners and their cats.Co...