ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

3. Thyroid

Thyroid development

ey0018.3-3 | Thyroid development | ESPEYB18

3.3. Generation and differentiation of adult tissue-derived human thyroid organoids

VML Ogundipe , AH Groen , N Hosper , PWK Nagle , J Hess , H Faber , AL Jellema , M Baanstra , TP Links , K Unger , JTM Plukker , RP Coppes

Stem Cell Reports. 2021;16:913–925. doi: 10.1016/j.stemcr.2021.02.011.In analogy to historical data [1], the authors provide important proof of principle that adult thyroid tissues cultivated in vitro show self-renewal and differentiation capacities and might ultimately be of use for regenerative autologous transplantation back into the donor patient affected by hypothyr...

ey0018.3-4 | Thyroid development | ESPEYB18

3.4. Single-cell transcriptome analysis reveals thyrocyte diversity in the zebrafish thyroid gland

P Gillotay , M Shankar , B Haerlingen , E Sema Elif , M Pozo-Morales , I Garteizgogeascoa , S Reinhardt , A Krankel , J Blasche , A Petzold , N Ninov , G Kesavan , C Lange , M Brand , A Lefort , F Libert , V Detours , S Costagliola , S Sumeet Pal

EMBO Rep. 2020;21:e50612. doi: 10.15252/embr.202050612.This zebrafish study identified and molecularly characterized adult transcriptionally different thyrocyte subpopulations even within the same follicle.It is well established that within a thyroid gland, follicles are heterogenous concerning functional activity. More active follicles are characterized by a high co...