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Yearbook of Paediatric Endocrinology 2021

3. Thyroid

Thyroid hormone action

ey0018.3-2 | Thyroid hormone action | ESPEYB18

3.2. A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver

Y Shabtai , NK Nagaraj , K Batmanov , YW Cho , Y Guan , C Jiang , J Remsberg , D Forrest , MA Lazar

Genes Dev. 2021;35(5–6):367–378. doi: 10.1101/gad.345686.120.The longstanding concept of thyroid hormone (TH) action is summarized as the canonical switch model. This study adds important aspects of TH action to our current understanding, modifying this longstanding switch model to a “shift” model.According to the current concept, TH dependent gene...