ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

8. Adrenals

New Concerns

ey0018.8-12 | New Concerns | ESPEYB18

8.12. First-Trimester prenatal dexamethasone treatment is associated with alterations in brain structure at adult age

A Van't Westeinde , L Karlsson , A Nordenstrom , N Padilla , S Lajic

J Clin Endocrinol Metab. 2020; 105(8):dgaa340., the authors investigated whether prenatal treatment with dexamethasone (DEX) in the first trimester is associated with alterations of brain morphology on MRI scans. Observed MRI alterations were not linked to any alterations in cognitive function or mood, but were associated with DNA methylation in ...

ey0018.8-13 | New Concerns | ESPEYB18

8.13. Perturbed beta-cell function and lipid profile after early prenatal dexamethasone exposure in individuals without CAH

L Wallensteen , L Karlsson , V Messina , A Nordenstrom , S Lajic

J Clin Endocrinol Metab. 2020;105(7): e2439-48., the authors investigated the effects of dexamethasone (DEX) on metabolism in individuals without CAH but treated with DEX during the first trimester of fetal life. Prenatal DEX exposure was associated with decreased beta-cell function and higher cholesterol concentrations.Pre...