ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2022

12. Type 2 Diabetes, Metabolic Syndrome and Lipids

New data on complications of children with T2DM

ey0019.12-3 | New data on complications of children with T2DM | ESPEYB19

12.3. Long-term complications in youth-onset type 2 diabetes

P. TODAY Study Group, Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler

The New England Journal of Medicine 2021;385(5):416-26. doi: 10.1056/NEJMoa2100165Brief Summary: This multicenter observational study assessed the cumulative incidence of diabetic complications in 500 adolescents with Type 2 diabetes (T2DM), followed from 2011 to 2020. After only 13 years from T2DM diagnosis, higher complication rates were observed than those reported for pediatric patients wit...

ey0019.12-4 | New data on complications of children with T2DM | ESPEYB19

12.4. Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

J. Fanelli G, Franke B, De Witte W, Ruisch IH, Haavik J, van Gils V, Jansen WJ, Vos SJB, Lind L, Buitelaar JK, Banaschewski T, Dalsgaard S, Serretti A, Mota NR, Poelmans G, Bralten

Translational psychiatry 2022;12(1):59. doi: 10.1038/s41398-022-01817-0Brief Summary: This population genetics study explored pairwise genome-wide genetic correlations between neuropsychiatric disorders with insulin-related somatic diseases and traits. There were likely protective effects of obsessive-compulsive disorder and anorexia nervosa on the risks of having MetS, obesity and T2DM; i...

ey0019.12-5 | New data on complications of children with T2DM | ESPEYB19

12.5. The time is now for new, lower diabetes diagnostic thresholds

BE Schwartz SS, Rachfal AW, Corkey

Trends in endocrinology and metabolism. 2022;33(1):4-7. doi: 10.1016/j.tem.2021.10.007Brief Summary: In this perspective, the authors propose to remove the term prediabetes and shift the paradigm to include current glycemic thresholds for prediabetes as diabetes.Comment: In 2001, a group of experts defined the term prediabetes to raise aware...