ISSN 1662-4009 (online)

Previous issue | Volume 19 | ESPEYB19 | Next issue

Yearbook of Paediatric Endocrinology 2022

15. Editors’ Choice

Assorted Conditions

ey0019.15-8 | Assorted Conditions | ESPEYB19

15.8. Serum testosterone levels in 3-month-old boys predict their semen quality as young adults

Henriksen L Scheutz , Petersen J Holm , NE Skakkebaek , N Jorgensen , HE Virtanen , L Priskorn , A Juul , J Toppari , KM Main

J Clin Endocrinol Metab. 2022;107(7):1965-75. doi: 10.1210/clinem/dgac173.PubMed ID: 35323957Brief summary: This population-based birth cohort study related infancy serum testosterone concentrations at age 3 months to parameters of reproductive function at age 18 to 20 years in 259 males. Serum testosterone in infancy predicted adult total sperm counts, and other reproductive hormones and geni...

ey0019.15-9 | Assorted Conditions | ESPEYB19

15.9. Genetic insights into biological mechanisms governing human ovarian ageing

KS Ruth , FR Day , J Hussain , A Martinez-Marchal , CE Aiken , A Azad , DJ Thompson , et al.

Nature. 2021;596(7872):393-7. doi: 10.1038/s41586-021-03779-7.PubMed ID: 34349265Brief summary: This study analysed genome-wide association array (GWAS) data on ~200 000 women of European ancestry to identify 290 separate genetic signals associated with normal variation in age at natural menopause (ANM). Experimental alterations of key identified genes in mouse models confirmed their impac...

ey0019.15-10 | Assorted Conditions | ESPEYB19

15.10. Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma

P Kachroo , ID Stewart , RS Kelly , M Stav , K Mendez , A Dahlin , DI Soeteman , SH Chu , M Huang , M Cote , HM Knilhtila , K Lee-Sarwar , M McGeachie , A Wang , AC Wu , Y Virkud , P Zhang , NJ Wareham , EW Karlson , CE Wheelock , C Clish , ST Weiss , C Langenberg , JA Lasky-Su

Nat Med. 2022;28(4):814-22. doi: 10.1038/s41591-022-01714-5.PubMed ID: 35314841Brief summary: This study performed large-scale metabolomic profiling across 14 000 adults from 4 cohorts and identified 17 steroid metabolites whose levels were reduced in individuals with prevalent asthma. The largest reductions were associated with inhaled corticosteroid (ICS) treatment, and these were valida...

ey0019.15-11 | Assorted Conditions | ESPEYB19

15.11. Evidence that ageing yields improvements as well as declines across attention and executive functions

J Verissimo , P Verhaeghen , N Goldman , M Weinstein , MT Ullman

Nat Hum Behav. 2022;6(1):97-110. doi: 10.1038/s41562-021-01169-7. PubMed ID: 34413509Brief summary: This cross-sectional study of adults (N=702) aged 58–98 measured cognitive abilities across a range of domains (alerting, orienting and executive inhibitory networks) by use of a computer-based Attention Network Test. In non-linear regression models, while efficiency of the ale...

ey0019.15-12 | Assorted Conditions | ESPEYB19

15.12. One statistical analysis must not rule them all

EJ Wagenmakers , A Sarafoglou , B Aczel

Nature. 2022;605(7910):423-5. doi: 10.1038/d41586-022-01332-8.PubMed ID: 35581494Brief summary: This Nature comment was prompted by the very wide range of calculated values for the COVID-19 infections ‘reproduction number’ R, produced by different modelling teams despite access to the same datasets on UK’s emerging ‘2nd wave’ in October 2020. Valu...

ey0019.15-13 | Assorted Conditions | ESPEYB19

15.13. The effects of remote work on collaboration among information workers

L Yang , D Holtz , S Jaffe , S Suri , S Sinha , J Weston , C Joyce , N Shah , K Sherman , B Hecht , J Teevan

Nat Hum Behav. 2022;6(1):43-54. doi: 10.1038/s41562-021-01196-4.PubMed ID: 34504299Brief summary: This study analysed a large database of emails, calendars, instant messages, video/audio calls and workweek hours routinely generated by 61 182 US Microsoft employees in the months before and after 4th March 2020, when the company mandated that all non-essential employees change to full-time w...