ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2022

15. Editors’ Choice

New Hormones

ey0019.15-6 | New Hormones | ESPEYB19

15.6. A hormone complex of FABP4 and nucleoside kinases regulates islet function

KJ Prentice , J Saksi , LT Robertson , GY Lee , KE Inouye , K Eguchi , A Lee , O Cakici , E Otterbeck , P Cedillo , P Achenbach , AG Ziegler , ES Calay , F Engin , GS Hotamisligil

Nature. 2021;600(7890):720-6. doi: 10.1038/s41586-021-04137-3.PubMed ID: 34880500Brief summary: This mouse study identifies FABP4 (‘Fabkin’) as a new fat-derived hormone that regulates insulin-producing beta cells in the pancreas.We have learnt over the recent years that body fat is not simply a passive energy storage tissue, but instead secretes a number o...

ey0019.15-7 | New Hormones | ESPEYB19

15.7. A nutrient-specific gut hormone arbitrates between courtship and feeding

HH Lin , MC Kuang , I Hossain , Y Xuan , L Beebe , AK Shepherd , M Rolandi , JW Wang

Nature. 2022;602(7898):632-8. doi: 10.1038/s41586-022-04408-7.PubMed ID: 35140404Brief summary: This study in the fruit-fly, Drosophila melanogaster, identified a novel gut-derived, nutrient-specific neuropeptide hormone, ‘Diuretic hormone 31’ (Dh31), which triggers the insects to switch their behaviour from feeding to courtship and reproduction.Romantic di...