ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2022

8. Adrenals

New Mechanisms

ey0019.8-2 | New Mechanisms | ESPEYB19

8.2. Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated NR3C1 gene

SG Caradonna , NR Einhorn , V Saudagar , H Khalil , GH Petty , A Lihagen , C LeFloch , FS Lee , H Akil , A Guidotti , BS McEwen , E Gatta , J Marrocco

Transl Psychiatry. 2022; 12(1): 109. PMID: 35296634 Summary: This mouse study identified sex and genotype-dependent effects of oral corticosterone on behavioral and physiological outcomes as well as on gene expression and epigenetics in hippocampal subregions.Glucocorticoids exert their effects by binding to glucocorticoid...

ey0019.8-3 | New Mechanisms | ESPEYB19

8.3. DNA methylation signatures in human neonatal blood following maternal antenatal corticosteroid treatment

B Kim , S Sasaki , K Murphy , SG Matthews

Transl Psychiatry. 2022; 12(1): 132. PMID: 35354798 Summary: This case control study identified widespread effects of fetal exposure to antenatal maternal glucocorticoid treatment on newborn bloodspot DNA methylation profiles.Antenatal treatment with glucocorticoids (AGC), such as betamethasone or dexamethasone, is widely u...