ESPE Yearbook of Paediatric Endocrinology

J Bone Miner Res. 2021 May;36(5):931–941. doi: 10.1002/jbmr.4262. PMID: 33507568.This restrospective study of the Cohort of Gender Dysphoria investigated bone geometry parameters of 106 adolescent trans-women and 216 adolescent trans-men during early and late start of gonadotropin-releasing hormone agonist (GnRHa) and gender affirming hormone therapy (GAHT). Transgender youth who started tr...

Brief summary: This paper investigated the effect of pubertal suppression with GnRHa and gender affirming treatment with testosterone on the growth and final height of transgender boys. They found no negative effects, and even possibly a slight boost to adult height in comparison with target and predicted heights for birth-registered sex.One of the concerning features of transgender males is being able to identify with their cisgender peers in stature. I...

Brief summary: Concerns exist that transgender adolescents opting for gender affirming treatments may subsequently regret their decision. This large study from Amsterdam provides information that in early adulthood, 98% of their cohort continued to access these treatments.The Amsterdam Cohort of Gender Dysphoria is one of the largest ongoing studies on the long-term outcomes of gender affirming hormone treatments (GAH). The authors presented outcomes at ...

To read the full abstract: Pediatrics. 2020, Mar; 145. doi: https://pediatrics.aappublications.org/content/pediatrics/145/3/e20190741.full.pdfCardiovascular health of transgender people was a hot topic in the transgender literature last year, triggered by previous findings that these individuals could have elevated risks for cardiovascular diseases b...

To read the full abstract: J Sex Med. 2018 15(4)This is an important paper with a follow-up covering more than 11,000 GD patients from a single clinic in the Netherlands, looking after most (>95%) of the GD patients of the country. Long-term follow-up to adulthood of children and adolescents with GD is still lacking as the recent rapid increase of these groups has not yet resulted in sub...

Brief summary: The World Professional Association for Transgender Health (WPATH) has issued an updated Standards of Care version 8 which contains important guidelines on how the assessment of gender variant children and adolescents should be considered, and by whom, and provides guidance around the consideration of young people for hormonal intervention.This long and detailed document has had considerable input from many experts involved in transgender c...