ISSN 1662-4009 (online)

ey0018.9-5 | Surveillance strategies of endocrine complications | ESPEYB18

9.5. Beyond premature ovarian Insufficiency: staging reproductive aging in adolescent and young adult cancer survivors.

ACO Medica , BW Whitcomb , K Shliakhsitsava , AC Dietz , K Pinson , C Lam , SAD Romero , P Sluss , MD Sammel , HI Su

J Clin Endocrinol Metab. 2021;106: e1002–e1013. cross-sectional study applied a commonly used system to classify reproductive aging (Stages of Reproductive Aging Workshop +10 or ‘STRAW +10’) to 338 adolescents and young adult (AYA) cancer survivors (1). The study aimed to evaluate if STRAW +10 correctly identifies premature ovaria...

ey0016.4-9 | New Perspectives | ESPEYB16

4.9. Low IGF-I bioavailability impairs growth and glucose metabolism in a mouse model of human PAPPA2 p.Ala1033Val mutation

M Fujimoto , M Andrew , L Liao , D Zhang , G Yildirim , P Sluss , B Kalra , A Kumar , S Yakar , V Hwa , A Dauber

To read the full abstract: Endocrinology. 2019;160:1363–1376.Pregnancy-associated plasma protein A2 (PAPP-A2) is a metalloproteinase which, by cleaving IGFBP-3 and IGFBP-5, releases free IGF-I from the ternary complexes and regulates its bioavailability. PAPPA2 gene mutations (p.D643fs25* and p.Ala1033Val) have recently been described in various members of two unrelated fam...