ESPEYB15 10 Type 1 Diabetes Mellitus Prevention (4 abstracts)
10.20 Effect of hydrolyzed infant formula vs conventional formula on risk of T1DM. The TRIGR randomized clinical trial
Writing Group for the TRIGR Study Group , Knip M , Åkerblom HK , Al Taji E , Becker D , Bruining J , Castano L , Danne T , de Beaufort C , Dosch HM , Dupre J , Fraser WD , Howard N , Ilonen J , Konrad D , Kordonouri O , Krischer JP , Lawson ML , Ludvigsson J , Madacsy L , Mahon JL , Ormisson A , Palmer JP , Pozzilli P , Savilahti E , Serrano-Rios M , Songini M , Taback S , Vaarala , White NH , Virtanen SM & Wasikowa R
To read the full abstract: JAMA. 2018;319:38-48
Earlier observational studies showed that dietary exposure to complex proteins in newborns and early infants is associated with beta cell autoimmunity and increase the risk for T1DM. Several studies avoiding certain proteins, such as gluten and casein, have been conducted without reducing the risk for T1D in genetically susceptible children. Therefore, these authors conducted an elaborate clinical trial, which randomized 2159 children to either an extremely hydrolyzed formula or conventional formula milk. Unfortunately, the use of the extremely hydrolyzed formula did not change the occurrence of T1DM in the first 10 years of life. The results suggest that the use of an extremely hydrolyzed formula cannot be recommended to prevent T1DM in high risk children. However one point was not discussed in the paper. Infants were included with a mean age of 2 months. Before inclusion all had a different feeding including breast feeding or several formulas. The authors cannot exclude that an earlier intervention from the first day would have shown other results.
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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