ESPEYB15 3 Thyroid Thyroid stem cells (1 abstracts)
3.13 Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification
Serra M , Alysandratos KD , Hawkins F , McCauley KB , Jacob A , Choi J , Caballero IS , Vedaie M , Kurmann AA , Ikonomou L , Hollenberg AN , Shannon JM & Kotton DN
Center for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA, USA
To read the full abstract: Development 2017;144:3879-3893
Regenerative medicine techniques are being widely investigated for organs without regenerative capacity, such as lung. Whether pluripotent stem cell derived thyroid organoids will be used in the future as a regenerative medicine approach to treat hypothyroidism is unclear. In the context of an easily available, very cheap and non-invasive substitutive therapy with levothyroxine, the cost-risk balance clearly speaks against such a novel approach. However, as pneumocyte and thyroid follicular cell precursors share a key transcription factor, NKX2-1, research in the field of lung development always gives new insights into thyroid development. In 2015, these authors published a paper detailing the generation of differentiated and functionally active thyroid follicular cells from induced pluripotent stem cells1. Chemical activation of specific pathways resulted in successful lineage induction. In this current paper, they further optimized their protocols to independently generate thyroid and lung progenitors from mouse and human pluripotent stem cells, that are highly useful for regenerative medicine or in vitro pharmaceutical or developmental studies.
1. Kurmann AA, Serra M, Hawkins F, Rankin SA, Mori M, Astapova I, Ullas S, Lin S, Bilodeau M, Rossant J, Jean JC, Ikonomou L, Deterding RR, Shannon JM, Zorn AM, Hollenberg AN, Kotton DN. Regeneration of thyroid function by transplantation of differentiated pluripotent stem cells. Cell Stem Cell 2015;17:527-542.
Volume 15
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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