ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2019

8. Adrenals


ey0016.8-17 | Reviews | ESPEYB16

8.17. Autoimmune Addison's disease - An update on pathogenesis

A Hellesen , E Bratland , ES Husebye

To read the full abstract: Ann Endocrinol (Paris). 2018; 79(3): 157–163.This review summarizes the current knowledge regarding the genetic susceptibility to autoimmune Addison’s disease (AAD) and the genes outside the MHC complex associated with AAD. Fourteen genes (CTLA-4, PD-L1, PTPN22, NALP1, STAT4, CIITA, BACH2, FCRL3, GPR174, GATA3, NFATC1, CLEC16A, CYP27B1, and VDR) have ...

ey0016.8-18 | Reviews | ESPEYB16

8.18. Developmental programming of the HPA axis and related behaviours: epigenetic mechanisms

S Matthews , P McGowan

To read the full abstract: J Endocrinol. 2019; 242(1):T69–T79.Maternal exposure to glucocorticoid therapy, or stress and anxiety during pregnancy, have been linked to alterations in the exposed offspring in their functioning of the hypothalamic-pituitary-adrenal (HPA) axis and stress-related behaviours. Moreover, it appears that these effects are maintained across multiple generatio...