ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Mol Genet Genomic Med. 2019;7(11):e956. doi: 10.1002/mgg3.956Short summary: Nine boys with Fragile X syndrome (FXS), aged between 2 to 7 years old, received off-label treatment with metformin for at least 3 months. Language development and behaviour improved in the majority of children. A controlled trial of metformin in very young children with FXS, whose brai...

To read the full abstract: Diabetes Care. 2019;42(9):1816–23. doi: 10.2337/dc19-0430Short summary: In this longstanding cohort study (n =1718), high intraindividual variability over time in BMI and in HDL-C during childhood, independent of their mean levels, conferred an increased risk of later-life diabetes.Comment: Intraindividual variabil...

To read the full abstract: J Hepatol. 2019;71(4):802–10. doi: 10.1016/j.jhep.2019.06.023Short summary: Prediabetes is highly prevalent in Caucasian children and adolescents with well-characterized, biopsy-proven non-alcoholic fatty liver disease (NAFLD).Comment: NAFLD is considered the liver presentation of the metabolic syndrome. NAFLD enco...

To read the full abstract: Cell Metab. 2020;31(1):92–104 e5. doi: 10.1016/j.cmet.2019.11.004Short summary: Ten-hour time-restricted eating (TRE) for 12 weeks in adults with metabolic syndrome treated with standard medical care resulted in weight loss, decreased waist circumference, and lower blood pressure and levels of cardiovascular disease-promoting lipids.<p class=...