ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2020

2. Antenatal and Neonatal Endocrinology

Maternal Obesity and Long-Term Infant Consequences

ey0017.2-17 | Maternal Obesity and Long-Term Infant Consequences | ESPEYB17

2.17. Children exposed to maternal obesity or gestational diabetes mellitus during early fetal development have hypothalamic alterations that predict future weight gain

KA Page , S Luo , X Wang , T Chow , J Alves , TA Buchanan , AH Xiang

To read the full abstract: Diabetes Care. 2019 Aug;42(8):1473–1480. PMID: 31332028Maternal obesity and gestational diabetes (GDM) increase the risk of offspring developing childhood obesity and type 2 diabetes. The underlying mechanisms and possible neuronal pathways are unknown but might involve changes in the hypothalamic structure and function. Novel non-invasive imaging te...

ey0017.2-18 | Maternal Obesity and Long-Term Infant Consequences | ESPEYB17

2.18. Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice

LM Nicholas , M Nagao , LC Kusinski , DS Fernandez-Twinn , L Eliasson , SE Ozanne

To read the full abstract: Diabetologia. 2020 Feb;63(2):324–337. PMID:31773193Maternal obesity is a risk factor for the development of type 2 diabetes in the offspring. Exposure to maternal obesity alters pancreatic islet structure and function, including reduced beta-cell mass and impaired glucose stimulated insulin secretion, which both increase susceptibility to type 2 diab...

ey0017.2-19 | Maternal Obesity and Long-Term Infant Consequences | ESPEYB17

2.19. Prolonged prepregnant maternal high-fat feeding reduces fetal and neonatal blood glucose concentrations by enhancing fetal [beta]-cell development in C57BL/6 mice

L Qiao , JS Wattez , L Lim , PJ Rozance , WW Jr Hay , J Shao

To read the full abstract: Diabetes. 2019 Aug;68(8):1604–1613. doi: 10.2337/db18-1308. Epub 2019 May 24. PMID: 31127056Maternal obesity is an important risk factor for neonatal hypoglycaemia. Maternal BMI predicts the risk of neonatal hypoglycaemia independently from maternal obesity suggesting that the link between maternal adiposity and neonatal hypoglycaemia is complex. Identifying the u...