ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2020

5. Bone, Growth Plate and Mineral Metabolism

Advances in Clinical Practice

ey0017.5-2 | Advances in Clinical Practice | ESPEYB17

5.2. Osteogenesis Imperfecta: Skeletal outcomes after bisphosphonate discontinuation at final height

ME Robinson , P Trejo , T Palomo , FH Glorieux , F Rauch

To read the full abstract: J Bone Miner Res. 2019 Dec;34(12):2198–2204.In brief: In Osteogenesis imperfecta (OI), intravenous (IV) cyclical bisphosphonates are often discontinued after cessation of growth in adolescents. This study showed that, four years after discontinuation of treatment, none of the patients sustained new vertebral compression fractures, and the proportion ...

ey0017.5-3 | Advances in Clinical Practice | ESPEYB17

5.3. Skeletal changes following hematopoietic stem cell transplantation in osteopetrosis

G Shapiro , J Fishleder , P Stepensky , N Simanovsky , V Goldman , R Lamdan

To read the full abstract: J Bone Miner Res. 2020 Apr 24. doi: brief: Hematopoietic stem cell transplantation remains the only curative treatment in children with severe osteopetrosis. According to this study, increased serum calcium and phosphate serve as good markers of successful engraftment, which leads to significant but incomplete n...

ey0017.5-4 | Advances in Clinical Practice | ESPEYB17

5.4. Effects of estrogen replacement on bone geometry and microarchitecture in adolescent and young adult oligoamenorrheic athletes: A randomized trial

KE Ackerman , V Singhal , M Slattery , KT Eddy , ML Bouxsein , H Lee , A Klibanski , M Misra

To read the full abstract: J Bone Miner Res. 2020;35(2):248–260.In brief: This randomized open-label trial in oligoamenorrheic athletes evaluated the effects of transdermal estrogen, oral estrogen or no replacement on bone metabolism, geometry, and microarchitecture. Transdermal estrogen treatment resulted in significantly greater increases in volumetric bone mineral d...

ey0017.5-5 | Advances in Clinical Practice | ESPEYB17

5.5. Six-year follow-up of a trial of antenatal vitamin D for asthma reduction

AA Litonjua , VJ Carey , N Laranjo , BJ Stubbs , H Mirzakhani , GT O’Connor , M Sandel , A Beigelman , LB Bacharier , RS Zeiger , M Schatz , BW Hollis , ST Weiss

To read the full abstract: N Engl J Med. 2020;382(6):525–533.In brief: High dose vitamin D supplementation of 4400 IU compared with 400 IU during the prenatal period alone to mothers of offspring at risk for asthma did not influence the incidence of asthma and recurrent wheeze in children aged 6-years.Commentary: Vitamin D deficiency has been im...

ey0017.5-6 | Advances in Clinical Practice | ESPEYB17

5.6. Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children

A Kampe , M Enlund-Cerullo , S Valkama , E Holmlund-Suila , J Rosendahl , H Hauta-Alus , M Pekkinen , S Andersson , O Makitie

To read the full abstract: PLoS Genet. 2019 Dec 16;15(12):e1008530.In brief: This genome-wide association study in a cohort of healthy infants shows that, already during the first two years of life, genetic variation in the genes encoding Vitamin D binding protein and Vitamin D 25-hydroxylase correlate with serum 25(OH)D levels and responses to vitamin D supplementation.<p clas...