Novel Receptor Signaling Mechanisms

ey0017.5-10 | Novel Receptor Signaling Mechanisms | ESPEYB17

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

S Nishimori , MJ O’Meara , CD Castro , H Noda , M Cetinbas , J da Silva Martins , U Ayturk , DJ Brooks , M Bruce , M Nagata , W Ono , CJ Janton , ML Bouxsein , M Foretz , R Berdeaux , RI Sadreyev , T Gardella , H Juppner , HM Kronenberg , MN Wein

To read the full abstract: J Clin Invest 2019;129:51875203.In brief: This report establishes inhibition of salt-inducible kinases as a central mechanism by which the parathyroid hormone 1 receptor (PTH1R) exerts its effects in both growth plate chondrocytes and osteoblasts/osteocytes during skeletal development, growth, and remodelling.Commentary</e...

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ey0017.5-11 | Novel Receptor Signaling Mechanisms | ESPEYB17

5.11. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

PP Centeno , A Herberger , H. Mun

To read the full abstract: Nat Commun 10, 4693 (2019).In brief: A specific anion binding site senses moderate changes of inorganic phosphate levels leading to rapid inhibition of CaSR responsiveness and PTH secretion in a murine and human in vitro model system.Commentary: Phosphate sensing represents a crucial process in the regulation of ph...

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ESPE Yearbook of Paediatric Endocrinology

Yearbook of Paediatric Endocrinology 2020

5. Bone, Growth Plate and Mineral Metabolism

5.10. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodelling

5.11. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

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