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Yearbook of Paediatric Endocrinology 2020

8. Adrenals

Clinical Trials - New Treatments

ey0017.8-8 | Clinical Trials - New Treatments | ESPEYB17

8.8. Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing’s syndrome (SONICS): A phase 3, multicentre, open-label, single-arm trial

M Fleseriu , R Pivonello , A Elenkova , R Salvatori , RJ Auchus , RA Feelders , EB Geer , Y Greenman , P Witek , F Cohen , BMK Biller

To read the full abstract: Lancet Diabetes Endocrinol. 2019; 7(11): 855-865. PMID: 31542384A.Endogenous Cushing’s syndrome is a rare, serious endocrine condition characterized by chronic overproduction of cortisol (1). It is most often caused by a pituitary adenoma (i.e. Cushing’s disease), while other causes include ectopic ACTH secretion or primary adrenal neopl...