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Yearbook of Paediatric Endocrinology 2020

8. Adrenals

New Mechanisms

ey0017.8-2 | New Mechanisms | ESPEYB17

8.2. Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization

K Van Looveren , M Van Boxelaere , Z Callaerts-Vegh , C Libert

To read the full abstract: PLoS One. 2019; 14(12): e0226753. PMID: 31869387.Glucocorticoids (cortisol in humans, corticosterone in most rodents) are steroid hormones secreted by the adrenal cortex into the systemic circulation in an ultradian, circadian, and stress-related fashion under the control of the hypothalamic-pituitary-adrenal (HPA) axis. These cholesterol-derived molecules partici...