ISSN 1662-4009 (online)

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Yearbook of Paediatric Endocrinology 2021

2. Antenatal and Neonatal Endocrinology

Fetal and Neonatal Cortisol and Growth Hormone Physiology

ey0018.2-21 | Fetal and Neonatal Cortisol and Growth Hormone Physiology | ESPEYB18

2.21. Evaluating the low-dose ACTH stimulation test in neonates: ideal times for cortisol measurement.

R LeDrew , E Bariciak , R Webster , N Barrowman , A Ahmet

J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa635. doi: 10.1210/clinem/dgaa635. PMID: 32901267.The authors performed a retrospective analysis of low dose synacthen tests performed in 49 neonates from January 1, 2009 to September 30, 2017 in a tertiary-care pediatric center. Of samples measured at 15, 30, and 60 minutes, the majority of neonates showed a peak cortisol level at 60 minutes.<...

ey0018.2-22 | Fetal and Neonatal Cortisol and Growth Hormone Physiology | ESPEYB18

2.22. The utility of a random growth hormone level in determining neonatal growth hormone sufficiency

L Mamilly , AL Pyle-Eilola , M Chaudhari , RK Henry

Clin Endocrinol (Oxf). 2021 Mar;94(3):392–398. doi: 10.1111/cen.14364. PMID: 33140844.In this retrospective study, random growth hormone (GH) levels were compared between newborns (mean age 9.07±6.6 days) with or without GH deficiency. A cut off of 4.5 ng/ml was established as the GH value to diagnose congenital GH deficiency. This value had a 100% sensitivity and 85% specificity for d...