ISSN 1662-4009 (online)

ey0020.14-11 | Section | ESPEYB20

14.11. Effect of thyroid hormone and growth hormone on recovery from hypothyroidism of epiphyseal growth plate cartilage and its adjacent bone

D Lewinson , Z Harel , P Shenzer , M Silbermann , Z Hochberg

Ze’ev Hochberg was fascinated by growth, a dominant topic during his long-standing career. He published 153 articles on growth according to PubMed, the first 1980 [1] and the last in April this year [2]. Synergy between thyroid hormones and growth hormone was recognized decades ago [3] but Ze’ev Hochberg added an important piece of knowledge on the impact of hypothyroidism on the growth plate as well as the effects of thyroid hormones, growth hormone and the combinat...

ey0020.14-12 | Section | ESPEYB20

14.12. The effect of single-dose radiation on cell survival and growth hormone secretion by rat anterior pituitary cells

Z Hochberg , A Kuten , P Hertz , M Tatcher , A Kedar , A Benderly

Brief summary: this early experimental study analyzed the effects of radiation on growth hormone secretion and short-term cell survival in a cell culture model of dispersed rat anterior pituitary cells.At the time of this study, growth retardation had already been recognized as a significant adverse effect of brain irradiation in humans and experimental animals. Such growth retardation had been associated with impaired secretion of growth hormone in chil...

ey0018.2-20 | Maternal Obesity and Long-term Infant Consequences | ESPEYB18

2.20. Maternal obesity influences placental nutrient transport, inflammatory status, and morphology in human term placenta

P Nogues , E Dos Santos , A Couturier-Tarrade , P Berveiller , L Arnould , E Lamy , S Grassin-Delyle , F Vialard , MN Dieudonne

J Clin Endocrinol Metab. 2021 Mar 25;106(4):e1880–e1896. doi: 10.1210/clinem/dgaa660. PMID: 32936881.By studying placentas from normal weight mothers and obese (non-diabetic) mothers, the authors found that maternal obesity was associated with lower expression of nutrient transporters (such as for glucose and amino acids), surprisingly fewer immune cells, and compromised endocrine func...

ey0019.8-5 | Important for Clinical Practice | ESPEYB19

8.5. Adrenal steroids reference ranges in infancy determined by LC-MS/MS

EO Enver , P Vatansever , O Guran , L Bilgin , P Boran , S Turan , G Haklar , A Bereket , T Guran

Pediatr Res. 2021; 92(1):265-274. doi: 10.1038/s41390-021-01739-5. PMID: 34556810https://pubmed.ncbi.nlm.nih.gov/34556810/Brief Summary: This study provides a detailed set of normative reference values for steroidogenesis during the first 6 months of life, which may facilitate rapid testing of infants for steroidogenic disorders.<p...

ey0019.10-14 | Pathogenesis | ESPEYB19

10.14. An autoimmune stem-like CD8 T cell population drives type 1 diabetes

SV Gearty , F Dundar , P Zumbo , G Espinosa-Carrasco , M Shakiba , FJ Sanchez-Rivera , ND Socci , P Trivedi , SW Lowe , P Lauer , N Mohibullah , A Viale , TP DiLorenzo , D Betel , A Schietinger

Nature 2022;602(7895):156-161. https://pubmed.ncbi.nlm.nih.gov/34847567/Brief Summary: This study used a well-characterized mouse model of type 1 diabetes (T1D), the non-obese diabetic mouse (NOD), to examine the fate of CD8 T cells over the 5–30 week course of the disease. They found a stem-like autoimmune progenitor population in the pancreatic draining lymph nodes, which can self-re...

ey0016.5-12 | Clinical Guidance | ESPEYB16

5.12. Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia

D Haffner , F Emma , DM Eastwood , MB Duplan , J Bacchetta , D Schnabel , P Wicart , D Bockenhauer , F Santos , E Levtchenko , P Harvengt , M Kirchhoff , F Di Rocco , C Chaussain , ML Brandi , L Savendahl , K Briot , P Kamenicky , L Rejnmark , A Linglart

Nat Rev Nephrol. 2019 May 8. doi: 10.1038/s41581-019-0152-5. [PMID: 31068690].Abstract: www.ncbi.nlm.nih.gov/pubmed/?termZ31068690In brief: In this Evidence-Based Guideline on X-linked hypophosphataemia, the authors identify the criteria for diagnosis of this disease, provide guidance for medi...

ey0018.8-5 | Important for Clinical Practice | ESPEYB18

8.5. Improved urinary cortisol metabolome in addison disease: A prospective trial of dual-release hydrocortisone

S Espiard , J McQueen , M Sherlock , O Ragnarsson , R Bergthorsdottir , P Burman , P Dahlqvist , B Ekman , BE Engstrom , S Skrtic , J Wahlberg , PM Stewart , G Johannsson

J Clin Endocrinol Metab 2021; 106(3):814–825.https://pubmed.ncbi.nlm.nih.gov/33236103/Here, the authors performed a randomized, 12-week, crossover study in order to assess cortisol metabolism during dual-release hydrocortisone (DR-HC) and conventional hydrocortisone (TID-HC) therapy in patients with primary adrenal insufficiency (n=50). Healthy controls (n=124) were i...

ey0018.13-4 | Diabetes | ESPEYB18

13.4. Heat-stability study of various insulin types in tropical temperature conditions: New insights towards improving diabetes care

B Kaufmann , P Boulle , F Berthou , M Fournier , D Beran , I Ciglenecki , M Townsend , G Schmidt , M Shah , S Cristofani , P Cavailler , M Foti , L Scapozza

PLoS ONE 2021;16: e0245372. doi: 10.1371/journal.pone.0245372– According to pharmacopeia, unopened insulin vials must be stored in a refrigerator (2–8 °C) while storage at ambient temperature (25–28 °C) is usually permitted for the 4-week usage period during treatment– The authors investigated whether insulin remains stable and retains biological activity...

ey0019.2-16 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB19

2.16. Maternal glycemia during pregnancy and early offspring development: a prospective birth cohort study

P Wang , J Xie , XC Jiao , SS Ma , Y Liu , WJ Yin , RX Tao , HL Hu , Y Zhang , XX Chen , FB Tao , P Zhu

J Clin Endocrinol Metab. 2021 Jul 13;106(8):2279-2290. doi: 10.1210/clinem/dgab331. PMID: 33982055.Brief Summary: This prospective birth cohort study assessed the impact of maternal glycaemia on infant neurodevelopment at 12 months of age. Maternal glucose levels during pregnancy were associated with infant neurodevelopmental outcomes.High maternal blood glucose levels m...

ey0019.12-3 | New data on complications of children with T2DM | ESPEYB19

12.3. Long-term complications in youth-onset type 2 diabetes

P. TODAY Study Group, Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler

The New England Journal of Medicine 2021;385(5):416-26. doi: 10.1056/NEJMoa2100165Brief Summary: This multicenter observational study assessed the cumulative incidence of diabetic complications in 500 adolescents with Type 2 diabetes (T2DM), followed from 2011 to 2020. After only 13 years from T2DM diagnosis, higher complication rates were observed than those reported for pediatric patients wit...