ISSN 1662-4009 (online)

ey0018.8-11 | New Hope | ESPEYB18

8.11. New Horizons: Novel adrenal regenerative therapies

SR Bornstein , M Malyukov , C Heller , CG Ziegler , G Ruiz-Babot , A Schedl , B Ludwig , C Steenblock

J Clin Endocrinol Metab. 2020; 105(9): 3103–3107. this narrative review, the authors discuss the potential role of novel regenerative therapies for the treatment of adrenal insufficiency, including gene therapy and cell replacement strategies. More specifically, the authors discuss the heterogeneity in adrenal function in patients with Addison...

ey0016.8-2 | New Mechanisms | ESPEYB16

8.2. Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress

C Steenblock , MF Rubin de Celis , LF Delgadillo Silva , V Pawolski , A Brennand , M Werdermann , I Berger , A Santambrogio , M Peitzsch , CL Andoniadou , AV Schally , SR Bornstein

To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(51): 12997–13002.Humans are constantly challenged by multiple stressors, to which the body’s response and adaptation are essential. The adrenal gland plays a major role in the response to both physiological challenges and stress. Maintenance of the adrenal is partly accomplished by proliferation and differentiat...