ESPE Yearbook of Paediatric Endocrinology

Preface: The highlight of the year in basic thyroidology is the description of the molecular architecture of the thyroglobulin dimer. For decades, small pieces of knowledge were accumulated that are now integrated into the complete picture of the thyroglobulin glycoprotein three-dimensional structure as well as the few key functional hormonogenic tyrosine residues which allow thyroxine and tri-iodothyronine synthesis. Genetic research revealed new and unexpected molecular mech...