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Yearbook of Paediatric Endocrinology 2020

3. Thyroid

Mechanism of the year

ey0017.3-1 | Mechanism of the year | ESPEYB17

3.1. The structure of human thyroglobulin

F Coscia , A Taler-Verčič , VT Chang , L Sinn , FJ O’Reilly , T Izore , M Renko , I Berger , J Rappsilber , D Turk , J Lowe

To read the full abstract: Nature. 2020;578:627–630.In this extensive work, Coscia et al. determined the molecular architecture of the full-length human thyroglobulin (TG) at high resolution by cryo-electron microscopy and identified the four hormonogenic tyrosine residues which act either as mono- or di-iodotyrosine acceptor and donor sites (A-D) and allow the ultimate step of thyroid hormone synthesis – coupling of two di- o...