ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Clin Epigenetics. 2020; 12: 55. PMID: 32264940.A large body of evidence has documented the long-term consequences of adverse childhood experiences (ACEs) on social and health outcomes in later life (1). However, the underlying mechanisms remain unclear. Epigenetic mechanisms may explain the lasting effects of early life adversity (2</stron...

To read the full abstract: J Clin Endocrinol Metab. 2020; 105(4):1098-111. PMID: 31950148.Classical congenital adrenal hyperplasia (CAH) is characterized by impaired glucocorticoid, and often also mineralocorticoid, secretion and increased adrenal androgen production (1). Given the widespread expression of androgen and glucocorticoid receptors throughout the brain (...

To read the full abstract: Cereb Cortex. 2020; 30(5): 2777–2788. PMID: 31819952.Congenital adrenal hyperplasia (CAH), most commonly caused by 21-hydroxylase deficiency, is an autosomal recessively inherited life-threatening impairment in cortisol and, in the severe salt wasting form, aldosterone synthesis. The implementation of neonatal screening programs for CAH and the continuous imp...