ESPE Yearbook of Paediatric Endocrinology

Brief summary: This review provides an update on the possible actions of metformin beyond glucose regulation in the liver. It summarizes recent findings regarding its action in the gastrointestinal tract, on gut microbiota and tissue-resident immune cells and thereby gives insight into studies addressing its immune-modulating and anti-inflammatory effects for possible use as treatment against inflammation- and age-related diseases, as well as cancer. Current knowledge of metfo...

Current atherosclerosis reports 2022;24(4):265-75. doi: 10.1007/s11883-022-01000-2Brief Summary: This review article discusses emerging therapies targeted at specific genes, proteins and enzymes to selectively alter triglyceride (TG) metabolism.Comment: Hypertriglyceridemia is a long-neglected major cardiovascular disease (CVD) risk factor. Recent epidemiological dat...

Nature. 2022;605(7910):423-5. doi: 10.1038/d41586-022-01332-8.PubMed ID: 35581494Brief summary: This Nature comment was prompted by the very wide range of calculated values for the COVID-19 infections ‘reproduction number’ R, produced by different modelling teams despite access to the same datasets on UK’s emerging ‘2nd wave’ in October 2020. Valu...

Cochrane Database Syst Rev. 2021 Aug 23;8(8):CD008901.Division of Molecular Genetics and Department of Pediatrics, Columbia University Medical Center, New York, NY, USA. vvt2114@cumc.columbia.edu. PMID: 34424546Brief Summary: This systematic review evaluated the efficacy and safety of rhGH therapy in improving lung function, quality of life and clinical status of children and young adults (aged up t...

Biomedical and Environmental Sciences, 2021, 34(8): 623–631 doi: 10.3967/bes2021.086Brief Summary: This cross-sectional study identified associations between serum ferritin levels with dyslipidemia and the MetS in both adult men and women. In addition, significant associations were found for ferritin levels with the risks of insulin resistance, prediabetes and T2DM in women.<p class="abs...

qhfka9357@naver.com Integr Med Res 11 (2022) 100832. doi: 10.1016/j.imr.2022.100832Brief Summary: This systematic review found that East Asian traditional medicine (EATM) therapies may have beneficial effects in children with idiopathic short stature, however, high-quality studies are necessary.The authors reviewed 14 studies (...

To read the full abstract: J Clin Endocrinol Metab. 2019;104:5540–5546.This single center, retrospective study analyzed the prevalence and natural history of amiodarone associated thyroid disease in 190 children and young adults with detailed thyroid function tests. Amiodarone induced hypothyroidism (AIH) and thyrotoxicosis (AIT) are well known entities due to direct thyroid toxicity. Further, subclinical hypothyroidism (SCH) is caused by a...

Diabetes Care 2018;41:1125–1131. DOI: 10.2337/dc18-er09a)• Many people currently in need of insulin are unable to access it.• Unaffordable price of insulin is a major barrier.• These authors analyse the causes of unsatisfactory access to insulin from a U.S. and global perspective.This article identifies the various ...

Anthropol Anz. 2018 Jun 11;74(5):365–376. DOI: 10.1127/anthranz/2018/0828• This literature review evaluated the phenomenon of faster growth, earlier maturation and often taller adult height in migrant youth as compared to their non-migrant relatives.• The authors propose a new framework to understand growth regulation and determinants of adult heigh...

To read the full abstract: Diabetes Care. 2017;40:1249-1255Children and adolescents who present in ketoacidosis at manifestation of the disease might represent a subgroup of patients that may have less resilience factors in their families, less adherence to medical advice, might be less attentive to medical symptoms and might be less knowledgeable of medical issues. In addition, they may carry biolog...