ISSN 1662-4009 (online)

ey0016.6-13 | Food for Thought in Transgender Medicine | ESPEYB16

6.13. Parent reports of adolescents and young adults perceived to show signs of a rapid onset of gender dysphoria

L Littman

PLoS One. 2018 Aug 16;13(8):e0202330.doi: 10.1371/journal.pone.0202330. Erratum in: PLoS One. 2019 Mar 19;14(3):e0214157.A sharp and unexplained rise in the incidence of gender dysphoria has been observed worldwide among adolescents, especially natal girls. The causes and outcomes (in terms of persistence-desistence rates) of adolescent-onset gender dysphoria ar...

ey0015.14-13 | The nature of scientific progress | ESPEYB15

14.13 Tragedy, Perseverance, and Chance - The Story of CAR-T Therapy

L Rosenbaum

To read the full abstract: N Engl J Med 2017;377:1313-1315“In 2010, 5-year-old Emily Whitehead was diagnosed with acute lymphoblastic leukemia.” So begins this remarkable story of how Emily became the first child to receive CART-19 (chimeric antigen receptor T-cell) therapy. She remains alive and well, and her successful treatment re-energised a whole line of research &#8...

ey0018.8-13 | New Concerns | ESPEYB18

8.13. Perturbed beta-cell function and lipid profile after early prenatal dexamethasone exposure in individuals without CAH

L Wallensteen , L Karlsson , V Messina , A Nordenstrom , S Lajic

J Clin Endocrinol Metab. 2020;105(7): e2439-48.https://pubmed.ncbi.nlm.nih.gov/32433752/Here, the authors investigated the effects of dexamethasone (DEX) on metabolism in individuals without CAH but treated with DEX during the first trimester of fetal life. Prenatal DEX exposure was associated with decreased beta-cell function and higher cholesterol concentrations.Pre...

ey0016.14-8 | (1) | ESPEYB16

14.8. Temperature-dependent hypoxia explains biogeography and severity of end-Permian marine mass extinction

Penn Justin L. , Deutsch Curtis , Payne Jonathan L. , Sperling Erik A.

To read the full abstract: Science 07 Dec 2018: Vol. 362, Issue 6419, eaat1327These authors report the frequencies of Metabolic Index traits in living species and used these values to define a set of model ecophysiotypes. They then populated the model Permian ocean with each ecophysiotype, and found that ocean warming increases the metabolic O2 demand amid declining supply; t...

ey0017.4-11 | New perspectives | ESPEYB17

4.11. NPR2 Variants are frequent among children with familial short stature and respond well to growth hormone therapy

L Plachy , P Dusatkova , K Maratova , L Petruzelkova , D Zemkova , L Elblova , P Kucerova , L Toni , S Kolouskova , M Snajderova , Z Sumnik , J Lebl , S Pruhova

To read the full abstract: J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgaa037.This study aimed to assess the frequency of natriuretic peptide receptor type B gene (NPR2 ) variants in 87 children with familial short stature (FSS) and evaluate their response to GH therapy. By applying whole-exome or custom-targeted NGS panel sequencing, NPR2 variants were found in 5 children (5.7%) belonging to 4 families. These variants were cla...

ey0017.9-5 | Fertility-Related Issues | ESPEYB17

9.5. Leydig cell function in male survivors of childhood cancer: A report from the St Jude lifetime cohort study

W Chemaitilly , Q Liu , L van Iersel

To read the full abstract: J Clin Oncol. 2019;37(32):3018–3031. wassim.chemaitilly@stjude.orgThis retrospective study, with cross-sectional health outcomes analysis, evaluated Leydig cell function in 1516 childhood cancer survivors at a median duration of 22.0 years after cancer diagnosis. These patients are part of the St Jude Lifetime Cohort. An age- and sex-matched community control grou...

ey0016.7-8 | Environmental Factors and Puberty | ESPEYB16

7.8. Systematic review and meta-analysis of the association between childhood physical activity and age at menarche

L Calthorpe , S Brage , KK Ong

To read the full abstract: Acta Paediatr. 2019 Jun;108(6):1008–1015.This meta-analysis reviews the association between physical activity and age at menarche.The onset of puberty is a multifactorial trait including a wide range of genetic and environmental components. Age at menarche has been associated with several environmental factors such as ...

ey0018.1-16 | Pituitary Function and Viral Diseases | ESPEYB18

1.16 COVID-19 and the pituitary

S Frara , A Allora , L Castellino , L di Filippo , P Loli , A Giustina

Pituitary. 2021 Jun;24(3):465–481. doi: 10.1007/s11102-021-01148-1. PMID: 33939057.Frara et al. review the main endocrine manifestations of COVID-19 with its implications for pituitary diseases. The authors report on the possible direct and indirect involvement of the pituitary gland in COVID-19 infection, and also the impact of COVID-19 on the management of pituitary dise...

ey0017.2-19 | Maternal Obesity and Long-Term Infant Consequences | ESPEYB17

2.19. Prolonged prepregnant maternal high-fat feeding reduces fetal and neonatal blood glucose concentrations by enhancing fetal [beta]-cell development in C57BL/6 mice

L Qiao , JS Wattez , L Lim , PJ Rozance , WW Jr Hay , J Shao

To read the full abstract: Diabetes. 2019 Aug;68(8):1604–1613. doi: 10.2337/db18-1308. Epub 2019 May 24. PMID: 31127056Maternal obesity is an important risk factor for neonatal hypoglycaemia. Maternal BMI predicts the risk of neonatal hypoglycaemia independently from maternal obesity suggesting that the link between maternal adiposity and neonatal hypoglycaemia is complex. Identifying the u...

ey0016.8-1 | Mechanism of the Year: Endogenous glucocorticoids suppress immunopathology and promote host resistance to viral infection without compromising protective immunity | ESPEYB16

8.1. Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells

L Quatrini , E Wieduwild , B Escaliere , J Filtjens , L Chasson , C Laprie , E Vivier , S Ugolini

To read the full abstract: Nat Immunol. 2018; 19(9): 954–962.The immune system protects the host organism against infectious diseases, however, pathogen elimination frequently entails collateral tissue damage and inflammation, which decrease host fitness (1). Neuroendocrine-immune interactions play an important role in these regulatory processes (2, 3). Endogenous glucocorticoids (c...